Showing 1953–1968 of 7558 results

MSDC-0160

MSDC-0160 is a prototype mTOT-modulating insulin sensitizer being studied to treat diabetes and Alzheimer’s disease. Phase 2.

FPH2 (BRD-9424)

FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.

FPH1 (BRD-6125)

FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes.

FH1 (BRD-K4477)

FH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.

CRT0044876

CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.

CORM-3

CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

ZLN005

ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.

L-Mimosine

L-Mimosine is a non-protein amino acid, and acts as an iron chelator.

E3330

E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.

Pyridostatin Trifluoroacetate Salt

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

AP-III-a4 (ENOblock)

AP-III-a4 (ENOblock) is the first nonsubstrate analogue inhibitor of enolase with IC50 of 0.576 μM.

WS6

WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

WS3

WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.

Ribociclib (LEE011)

Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor. Phase 3.

ME0328

ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.

Sal003

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.