Dolasetron
Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. It has minimal activity at other known serotonin receptors, and has low affinity for dopamine receptors.
Showing 3281–3296 of 7558 results
Nitisinone
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase used in the treatment of hereditary tyrosinemia type 1.
Oxidopamine (Hydrobromide)
Oxidopamine is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity.
Sodium Gualenate
Sodium gualenate (Guaiazulenesulfonate sodium), a hydrophilic derivative of guaiazulene (GA), is an unstable compound, which is gradually decomposed in the solid state at room temperature. It has anti-inflammatory and wound-healing effects.
Y15
Y15 is a small-molecule FAK scaffolding inhibitor that directly inhibits FAK autophosphorylation in a dose- and time-dependent manner.
Octinoxate
Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
AWD 131-138
AWD 131-138 is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.
Acacetin
Acacetin is a flavonoid compound that has been shown to have anti-cancer, anti-mutagenic, anti-inflammatory and anti-peroxidative effects.
UK 5099
UK5099 is a potent inhibitor of the mitochondrial pyruvate carrier, inhibiting pyruvate transport across the plasma membrane of trypanosomes with Ki value of 49 μM.
NU2058
NU2058 is an inhibitor of CDK2 with IC50 value of 17 μM in an isolated enzyme assay. It also potentiates melphalan (DMF 2.3), and monohydroxymelphalan (1.7), but not temozolomide or ionising radiation.
PRT4165
PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro.
HTHQ(1-O-Hexyl-2,3,5-Trimethylhydroquinone)
HTHQ, which is a hydroquinone monoalkylether, is a potent anti-oxidative and anti-lipid-peroxidative agent.
SC66
SC66 is an allosteric inhibitor which displays a dual-inhibitory function toward AKT activity with IC50 values of 0.77, 2.85 and 0.47 μg/ml in HepG2, Huh7 and Hep3B cells after 72 h treatment, respectively.
Urolithin A
Urolithin A, a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.
Pyridoxal Phosphate
Pyridoxal phosphate, the active form of vitamin B6, acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids.
4,4′-Dimethoxybenzil
4,4′-Dimethoxybenzil is a biochemical that has been reported to have mesomorphic properties of a substituted bis(dithiolene)nickel complex derived from 4,4′-dimethoxybenzil.