Showing 5041–5056 of 7558 results

GSK256066

GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.

LDN-193189

LDN-193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.

TAK-733

TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.

Arecoline HBr

Arecoline is a muscarinic acetylcholine receptor agonist.

Clorsulon

Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.

Ribitol

Ribitol is a crystalline pentose alcohol and is formed by the reduction of ribose which is occurs naturally in the plant Adonis vernalis.

Ethisterone

Ethisterone is a progestogen hormone being considered to treat prostate cancer.

Lonidamine

Lonidamine is an orally administered small molecule hexokinase inactivator.

Inulin

Inulin(Inulin and sodium chloride), a starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, it is classified as a fructosan.

Fluocinonide

Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.

Buflomedil HCl

Buflomedil HCl is a vasodilator used to treat claudication or the symptoms of peripheral arterial disease A nonselective alpha adrenergic receptor inhibitor.

Mifepristone

Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively.

Idebenone

Idebenone is a synthetic analog of coenzyme Q10 (CoQ10) and a brain stimulant.

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist.

Tioxolone

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM.