Showing 3057–3072 of 5741 results

b-AP15

b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.

SN-38

SN-38 is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

SC-514

SC-514 is an orally active, ATP-competitive IKK-2 inhibitor with IC50 of 3-12 μM, blocks NF-κB-dependent gene expression, does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

JZL184

JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.

QNZ (EVP4593)

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.

JNK-IN-8

JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line.

Tenovin-6

Tenovin-6 is a small molecule activator of p53 transcriptional activity.

Sulfogaiacol

Sulfogaiacol is a antitussive agent that is used for acute respiratory tract infections, cough and other conditions.

Nortropine Hydrochloride

Nortropine Hydrochloride is a secondary metabolite of tropine derivative drugs, such as atropine and benztropine.

Elagolix Sodium

Elagolix Soidum is a potent, selective, orally active, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with Kd value of 54 pM. Concentration at 10 μM shows no significant activity on ion channels, enzymes, and transporters (inhibition <50%).

D-Glucurone

D-Glucurone is a glucuronic acid derivative that is used for treating canine hepatitis.

Cytosine

Cytosine is one of the four main bases found in DNA and RNA used in storing and transporting genetic information within a cell.

Phenibut

Phenibut, a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.

Bifendate

Bifendate, a synthetic intermediate of schisandrin C, is an anti-HBV drug used in Chinese medicine for the treatment of chronic hepatitis B.