Showing 5377–5392 of 5741 results

Mianserin HCl

Mianserin is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.

Meropenem

Meropenem is an ultra-broad spectrum injectable antibiotic.

Lopinavir

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

Isotretinoin

It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.

Ruxolitinib (INCB018424)

Ruxolitinib (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3.

Drospirenone

Drospirenone is a synthetic progestin that is an analog to spironolactone.

Gestodene

Gestodene is a progestogen hormonal contraceptive.

Dorzolamide HCl

Dorzolamide HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.

Doripenem Hydrate

Doripenem Hydrate is an ultra-broad-spectrum injectable antibiotic, used to treat complicated intra-abdominal infections and complicated urinary tract infections.

Daptomycin

Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.

Biapenem

Biapenem is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.

Bafetinib (INNO-406)

Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.

Acitretin

Acitretin is a second generation retinoid used for psoriasis.

Amonafide

Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. Phase 3.

BMS-707035

BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.