Showing 5425–5440 of 5741 results

Dexamethasone (DHAP)

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

Costunolide

Costunolide, a natural sesquiterpene compound with multiple biological activities inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.

AMG-208

AMG 208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.

Ki16425

Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM in RH7777 cell lines, respectively, shows no activity at LPA4, LPA5, LPA6.

Zoledronic Acid

Zoledronic acid (ZA), a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.

Streptozotocin (STZ)

Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

Pamidronate Disodium

Pamidronate Disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis.

Mercaptopurine (6-MP)

Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.

Megestrol Acetate

Megestrol acetate is a synthetic progestogen, used to treat breast cancer and loss of appetite.

Ifosfamide

Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.

Floxuridine

Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.

Epothilone A

Epothilone A is a paclitaxel-like microtubule-stabilizing agent with EC0.01 of 2 μM.

Cilostazol

Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

Cilnidipine

Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.