Showing 5441–5456 of 5741 results

Celastrol

Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.

Carmofur

Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer.

Camptothecin

Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Phase 2.

Bumetanide

Bumetanide (Bumex) is a loop diuretic of the sulfamyl category to treat heart failure.

Budesonide

Budesonide is a glucocorticoid steroid for the treatment of asthma, non-infectious rhinitis.

Benazepril HCl

Benazepril HCl is a novel angiotensin I converting enzyme inhibitor, used primarily in treatment of hypertension.

Asenapine Maleate

Asenapine maleate is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.

Artemisinin

Artemisinin is a sesquiterpene endoperoxide which is a potent antimalarial agent.

Aniracetam

Aniracetam is a nootropics and neuroprotective drug.

Amisulpride

Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.

Adapalene

Adapalene is a dual RAR and RXR agonist, used in the treatment of acne.

BX-912

BX912 is a potent and specific PDK1 inhibitor with IC50 of 12 nM, 9- and 105- fold greater selectivity for PDK1 than PKA and PKC in cell-free assays, respectively. In comparison to GSK3β, selectivity for PDK1 is 600-fold.

BX-795

BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1.

Acarbose

Acarbose is an inhibitor of intestinal alpha-glucosidase, used to treat type 2 diabetes mellitus.