Showing 961–976 of 5741 results

MS023

MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.

GSK591

GSK591 (EPZ015866,GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 4 nM.

GSK1016790A

GSK1016790A (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34nM in choroid plexus epithelial cells.

NSC59984

NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.

ZM241385

ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.

SCH58261

SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.

Sotagliflozin (LX4211)

Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.

CB-5083

CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.

K03861

K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.

C-DIM12

C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.

Mirin

Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.

GlyH-101

GlyH-101 is a selective and reversible CFTR inhibitor with Ki of 4.3 μM.

Bardoxolone Methyl

Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.

RI-1

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.

PluriSIn #1 (NSC 14613)

PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.