AKT1 Rabbit Recombinant mAb

46.00 390.00 

AKT1 Rabbit Recombinant mAb detects endogenous levels of total AKT1.

Category: SKU: A5023

Description

AKT1, a serine-threonine protein kinase, is also referred to as protein kinase B. It is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 has two related protein kinase, AKT2 and AKT3. They regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at Thr-145 induces its release from CDK2 and cytoplasmic relocalization.

Additional information

Application

ELISA, Immunohistochemistry, Western Blotting

Brand

bimake

Clonality

Monoclonal

Host

Rabbit

Reactivity

Human, Mouse, Rat

Storage

Store at -20°C

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