Description
Anti-Aquaporin-2 (AQP2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Aquaporin, also known as water channel, mediates water permeation across the cell membrane. There are approximately 10 aquaporin genes in human genome. Aquaporin proteins are composed of six transmembrane domains, three extracellular loops, two intracellular loops and two intracellular termini.
Aquaporin-2 is encoded by the Aqp2 gene in human. Aquaporin-2 is highly expressed in the collecting duct epithelium of the kidney. Mutations in Aqp2 gene cause diabetes insipidus.
This antibody can be used with anti-Atp6v1b1 or anti-Pendrin to differentiate the cell types in kidney collecting ducts.
