Anti-Aquaporin-2 (AQP2) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Aquaporin, also known as water channel, mediates water permeation across the cell membrane. There are approximately 10 aquaporin genes in human genome. Aquaporin proteins are composed of six transmembrane domains, three extracellular loops, two intracellular loops and two intracellular termini.
Aquaporin-2 is encoded by the Aqp2 gene in human. Aquaporin-2 is highly expressed in the collecting duct epithelium of the kidney. Mutations in Aqp2 gene cause diabetes insipidus.
This antibody is raised in rat and particularly suited for use as a molecular marker to label the collecting duct cells in co-localization studies.