Anti-Aquaporin-4 (AQP4) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Aquaporin, also known as water channel, mediates water permeation across the cell membrane. There are approximately 10 aquaporin genes in human genome. Aquaporin proteins are composed of six transmembrane domains, three extracellular loops, two intracellular loops and two intracellular termini.
Aquaporin-4 is encoded by the Aqp4 gene in human. Aquaporin-4 is not only expressed by epithelial tissues but also expressed by astrocytes in the central nervous system.