Anti-VE-cadherin (Cdh5 or Cadherin-5 or CD144) antibody is validated on mouse tissue and recommended for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
VE-cadherin is a protein that is encoded by the Cdh5 gene in human. VE-cadherin is also known as Cadherin-5 or CD144. VE-cadherin belongs to the classic cadherin protein superfamily.
The cadherin protein features an amino-terminal extracellular domain or ectodomain or EC domain that is followed by a transmembrane domain and a carboxyl-terminal intracellular domain. The cadherin ectodomain plays an adhesive role whereas the intracellular domain mediates cadherin-catenin interactions.
VE-cadherin is exclusively expressed in the endothelium. VE-cadherin is important for the integrity of adherens junction in the endothelium and the permeability across the endothelium.
This antibody is raised in rat and particularly suited for use as a molecular marker to label the endothelium in co-localization studies.