Anti-ZO-1 (Tjp1) (C-terminus) monoclonal antibody (F11 clone) is validated on mouse and human tissues and can be used for immunofluorescence labeling, IHC, or western blot of materials from rodent and human tissues.
Zonula occludens-1 (ZO-1), also known as tight junction protein-1 (TJP1) is a 220-kD tight junction peripheral protein encoded by the TJP1 gene in human. ZO-1 contains three PDZ domains, an SRC homology 3 (SH3) domain, and a yeast guanylate kinase homology (GUK) domain. ZO-1 can interact with tight junction integral proteins such as claudins and occludin and with the perijunctional cytoskeleton.
ZO-1 is expressed in a variety of epithelial tissues including the kidney, the intestines, the lung, the liver, the pancreas and more.