{"product_id":"1-naphthohydroxamic-acid-e6577","title":"1-Naphthohydroxamic acid","description":"\u003cp\u003e\u003cstrong\u003e1-Naphthohydroxamic acid\u003c\/strong\u003e is an inhibitor of HDAC used in studies of DNA Damage Response and Epigenetic Regulation. It is especially relevant in cancer, dna damage \/ repair, and epigenetics models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting HDAC, 1-Naphthohydroxamic acid can be used to examine checkpoint activation, DNA repair, and genome-stability control and chromatin-state control, histone modification, and transcriptional regulation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In cancer, dna damage \/ repair, and epigenetics models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving HDAC\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Epigenetic Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, 1-Naphthohydroxamic acid is appropriate when a defined chemical perturbant is needed to connect HDAC with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, dna damage \/ repair, and epigenetics models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805029540185,"sku":"E6577-5MG","price":194.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805029572953,"sku":"E6577-25MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805029605721,"sku":"E6577-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805029638489,"sku":"E6577-1G","price":2919.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E6577-chemical-structure.png?v=1776170921","url":"https:\/\/absource.de\/products\/1-naphthohydroxamic-acid-e6577","provider":"Absource Diagnostics","version":"1.0","type":"link"}