{"product_id":"1e-cfi-400437-dihydrochloride-s0371","title":"(1E)-CFI-400437 dihydrochloride","description":"\u003cp\u003e\u003cstrong\u003e(1E)-CFI-400437 dihydrochloride\u003c\/strong\u003e is an inhibitor of PLK4 used in studies of Cell Cycle Regulation. It is especially relevant in cancer, cell cycle, and cell signaling models, where defined compound exposure can be linked to checkpoint control, mitotic progression, and proliferation timing.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PLK4, (1E)-CFI-400437 dihydrochloride can be used to examine checkpoint control, mitotic progression, and proliferation timing. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell cycle, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PLK4\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Cell Cycle Regulation\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, (1E)-CFI-400437 dihydrochloride is appropriate when a defined chemical perturbant is needed to connect PLK4 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell cycle, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805111296345,"sku":"S0371-5MG","price":272.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s0371-1e-cfi-400437-dihydrochloride-chemical-structure.gif?v=1776172125","url":"https:\/\/absource.de\/products\/1e-cfi-400437-dihydrochloride-s0371","provider":"Absource Diagnostics","version":"1.0","type":"link"}