{"product_id":"2-methoxyestradiol-2-meoe2-s1233","title":"2-Methoxyestradiol (2-MeOE2)","description":"\u003cp\u003e\u003cstrong\u003e2-Methoxyestradiol (2-MeOE2)\u003c\/strong\u003e is an inhibitor of HIF used in studies of Cell Cycle Regulation and Apoptosis and related signaling programs. In practice, this places the compound in experiments that measure checkpoint control, mitotic progression, and proliferation timing and caspase-associated cell-death signaling and survival decisions in angiogenesis, apoptosis, and autophagy models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting HIF, 2-Methoxyestradiol (2-MeOE2) can be used to examine checkpoint control, mitotic progression, and proliferation timing and caspase-associated cell-death signaling and survival decisions. The signaling pathway modulator annotation adds relevance to pathway-reporter and mechanistic-phenotyping studies, together with downstream-response mapping in the same experimental setting. In angiogenesis, apoptosis, and autophagy models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving HIF\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Cell Cycle Regulation and Apoptosis and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePathway-reporter and mechanistic-phenotyping studies\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, 2-Methoxyestradiol (2-MeOE2) is appropriate when a defined chemical perturbant is needed to connect HIF with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, apoptosis, and autophagy models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 10 mg","offer_id":57805252591961,"sku":"S1233-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 50 mg","offer_id":57805252624729,"sku":"S1233-50MG","price":291.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 mg","offer_id":57805252657497,"sku":"S1233-100MG","price":383.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 g","offer_id":57805252690265,"sku":"S1233-1G","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 ml (10mM\/DMSO)","offer_id":57805252723033,"sku":"S1233-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 10 mg","offer_id":58478425702745,"sku":"C07640-10MG","price":108.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 50 mg","offer_id":58478425735513,"sku":"C16202-50MG","price":217.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 mg","offer_id":58478425768281,"sku":"C16202-100MG","price":285.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 1 g","offer_id":58478425801049,"sku":"C07640-1G","price":712.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/2-Methoxyestradiol-chemical-structure-S1233.gif?v=1776173181","url":"https:\/\/absource.de\/products\/2-methoxyestradiol-2-meoe2-s1233","provider":"Absource Diagnostics","version":"1.0","type":"link"}