{"product_id":"3-deazaadenosine-hydrochloride-s0787","title":"3-Deazaadenosine hydrochloride","description":"\u003cp\u003e\u003cstrong\u003e3-Deazaadenosine hydrochloride\u003c\/strong\u003e is an inhibitor of TNF-alpha used in studies of PI3K-Akt-mTOR Signaling and NF-kB Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and inflammatory transcriptional control and stress-responsive survival signaling in apoptosis, cancer, and immunology models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting TNF-alpha, 3-Deazaadenosine hydrochloride can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TNF-alpha\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and NF-kB Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, 3-Deazaadenosine hydrochloride is appropriate when a defined chemical perturbant is needed to connect TNF-alpha with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805144523097,"sku":"S0787-5MG","price":291.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805144555865,"sku":"S0787-25MG","price":883.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805144588633,"sku":"S0787-1ML\/DMSO","price":323.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s0787-3-deazaadenosine-hydrochloride-chemical-structure.gif?v=1776172489","url":"https:\/\/absource.de\/products\/3-deazaadenosine-hydrochloride-s0787","provider":"Absource Diagnostics","version":"1.0","type":"link"}