{"product_id":"4-pba-4-phenylbutyric-acid-s3592","title":"4-PBA (4-Phenylbutyric acid)","description":"\u003cp\u003e\u003cstrong\u003e4-PBA (4-Phenylbutyric acid)\u003c\/strong\u003e is an inhibitor of HDAC used in studies of DNA Damage Response and Autophagy and related signaling programs. It is especially relevant in autophagy, cancer, and dna damage \/ repair models, where defined compound exposure can be linked to checkpoint activation, DNA repair, and genome-stability control and autophagic flux, lysosomal turnover, and stress adaptation.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting HDAC, 4-PBA (4-Phenylbutyric acid) can be used to examine checkpoint activation, DNA repair, and genome-stability control and autophagic flux, lysosomal turnover, and stress adaptation. The epigenetic regulator annotation adds relevance to chromatin, epigenetic, and gene-expression profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving HDAC\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Autophagy and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eChromatin, epigenetic, and gene-expression profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, 4-PBA (4-Phenylbutyric acid) is appropriate when a defined chemical perturbant is needed to connect HDAC with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"100 mg","offer_id":57808914415961,"sku":"S3592-100MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg","offer_id":57808914448729,"sku":"S3592-500MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57808914481497,"sku":"S3592-1G","price":341.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s3592-benzenebutyric-acid-chemical-structure.gif?v=1776195086","url":"https:\/\/absource.de\/products\/4-pba-4-phenylbutyric-acid-s3592","provider":"Absource Diagnostics","version":"1.0","type":"link"}