{"product_id":"actn4-antibody-sc-f2033","title":"α Actinin 4 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eAlpha-actinin 4 (ACTN4) is an actin-binding protein that belongs to the spectrin superfamily. It plays a crucial role in actin cytoskeleton remodelling and the formation of protrusions that enhance the migration of normal and cancer cells. It acts as a co-activator and positive regulator for RelA\/p65 and as a transcription activator for ERα, RAR, myocyte enhancer factor (MEF), vitamin D receptor (VDR), androgen receptor (AR), and NF-κB transcription factors. Depending on the literature source, ACTN4 may also be discussed as alpha Actinin 4.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell junction, cytoplasm, cytoskeleton, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following ACTN4 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eACTN4 is commonly interpreted in the context of cancer and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell junction, cytoplasm, and cytoskeleton, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell junction, cytoplasm, and cytoskeleton across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ACTN4. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ACTN4 reflect biology rather than handling. When interpreting ACTN4, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ACTN4 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577847423321,"sku":"F2033-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577847456089,"sku":"F2033-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577847488857,"sku":"F2033-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2033-IHC1.jpg?v=1773600124","url":"https:\/\/absource.de\/products\/actn4-antibody-sc-f2033","provider":"Absource Diagnostics","version":"1.0","type":"link"}