{"product_id":"afatinib-dimaleate-s7810","title":"Afatinib Dimaleate","description":"\u003cp\u003e\u003cstrong\u003eAfatinib Dimaleate\u003c\/strong\u003e is an inhibitor of EGFR and HER2 used in studies of PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in autophagy, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting EGFR and HER2, Afatinib Dimaleate can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving EGFR and HER2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Afatinib Dimaleate is appropriate when a defined chemical perturbant is needed to connect EGFR and HER2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 10 mg","offer_id":57809543889241,"sku":"S7810-10MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 50 mg","offer_id":57809543922009,"sku":"S7810-50MG","price":242.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 200 mg","offer_id":57809543954777,"sku":"S7810-200MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 g","offer_id":57809543987545,"sku":"S7810-1G","price":776.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 1 ml (10mM\/DMSO)","offer_id":57809544020313,"sku":"S7810-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 10 mg","offer_id":58478995997017,"sku":"C12966-10MG","price":108.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 50 mg","offer_id":58478996029785,"sku":"C12966-50MG","price":180.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 200 mg","offer_id":58478996062553,"sku":"C12966-200MG","price":271.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 1 g","offer_id":58478996095321,"sku":"C12966-1G","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/afatinib-dimaleate-chemical-structure-s7810.gif?v=1776201885","url":"https:\/\/absource.de\/products\/afatinib-dimaleate-s7810","provider":"Absource Diagnostics","version":"1.0","type":"link"}