{"product_id":"ag-1478-s2728","title":"AG-1478","description":"\u003cp\u003e\u003cstrong\u003eAG-1478\u003c\/strong\u003e is an inhibitor of EGFR used in studies of PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling and related signaling programs. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling in cancer, cell signaling, and infectious disease models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting EGFR, AG-1478 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and mitogenic kinase cascades, proliferation control, and differentiation-linked signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and infectious disease models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving EGFR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and MAPK \/ ERK Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, AG-1478 is appropriate when a defined chemical perturbant is needed to connect EGFR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and infectious disease models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805707018585,"sku":"S2728-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805707051353,"sku":"S2728-10MG","price":223.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805707084121,"sku":"S2728-25MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805707116889,"sku":"S2728-1G","price":2545.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805707149657,"sku":"S2728-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/ag-1478-tyrphostin-ag-1478-chemical-structure-s2728.gif?v=1776175583","url":"https:\/\/absource.de\/products\/ag-1478-s2728","provider":"Absource Diagnostics","version":"1.0","type":"link"}