{"product_id":"agtr-2-antibody-sc-f2225","title":"Angiotensin II Type 2 Receptor Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eAGTR-2 is a target of interest in many antibody-based workflows. The Angiotensin II Type 2 Receptor (AT2R), a member of the G protein-coupled receptor (GPCR) family, is linked to stimulatory (Gαs) or inhibitory (Gαi\/o) proteins and G protein-independent pathways that involve AT2R binding proteins. Its activation triggers enzymes such as SHP-1 (SH2 domain-containing phosphatase 1), MKP-1 (mitogen-activated protein kinase phosphatase 1), and PP2A (protein phosphatase 2A), which play significant roles in signalling pathways. Depending on the literature source, AGTR-2 may also be discussed as Angiotensin II Type 2 Receptor.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane and membrane, which can matter when signal is compared across treatments or changing cell states. Following AGTR-2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eAGTR-2 is commonly interpreted in the context of immunology, inflammation, and cardiovascular research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003eresponses associated with cytokine exposure, inflammatory tone, or tissue stress\u003c\/li\u003e\n\u003cli\u003echanges linked to vascular, contractile, or hemodynamic cell-state cues\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for AGTR-2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in AGTR-2 reflect biology rather than handling. When interpreting AGTR-2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep AGTR-2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577898443097,"sku":"F2225-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577898475865,"sku":"F2225-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577898508633,"sku":"F2225-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2225-wb.gif?v=1773600286","url":"https:\/\/absource.de\/products\/agtr-2-antibody-sc-f2225","provider":"Absource Diagnostics","version":"1.0","type":"link"}