{"product_id":"aldh1a1-antibody-sc-f1023","title":"ALDH1A1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eThe aldehyde dehydrogenase family consists of enzymes that are responsible for oxidizing aldehydes produced during metabolic processes into their corresponding carboxylic acids. ALDH1A1, a liver cytosolic form of acetaldehyde dehydrogenase, is involved in the main pathway of alcohol metabolism alongside alcohol dehydrogenase. In ovarian cancer cells, ALDH1A1 increases the expression of DNA polymerase θ (Polθ) by activating the retinoic acid (RA) signaling pathway, leading to resistance to PARP inhibitors (PARPi).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and cytosol, which can matter when signal is compared across treatments or changing cell states. Following ALDH1A1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eALDH1A1 is commonly interpreted in the context of cancer, metabolism, and oxidative stress research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and cytosol, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and cytosol across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eredox-associated shifts that may alter abundance, localization, or pathway coupling\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ALDH1A1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ALDH1A1 reflect biology rather than handling. When interpreting ALDH1A1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ALDH1A1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577592062297,"sku":"F1023-20UL","price":179.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577592095065,"sku":"F1023-100UL","price":399.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577592127833,"sku":"F1023-2X100UL","price":599.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1023-IF.png?v=1773599200","url":"https:\/\/absource.de\/products\/aldh1a1-antibody-sc-f1023","provider":"Absource Diagnostics","version":"1.0","type":"link"}