{"product_id":"amg-487-s8682","title":"AMG 487","description":"\u003cp\u003e\u003cstrong\u003eAMG 487\u003c\/strong\u003e is an antagonist of CXCR used in studies of Immune Signaling and GPCR Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to cytokine-mediated signaling and inflammatory effector responses and receptor-driven second-messenger signaling and desensitization dynamics in immunology and inflammation models.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking CXCR, AMG 487 can be used to examine cytokine-mediated signaling and inflammatory effector responses and receptor-driven second-messenger signaling and desensitization dynamics. The gpcr annotation adds relevance to GPCR pharmacology, ligand-binding, and signaling assays, together with downstream-response mapping in the same experimental setting. In immunology and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CXCR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Immune Signaling and GPCR Signaling\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eGPCR pharmacology, ligand-binding, and signaling assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, AMG 487 is appropriate when a defined chemical perturbant is needed to connect CXCR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809634263385,"sku":"S8682-5MG","price":254.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809634296153,"sku":"S8682-25MG","price":763.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809634328921,"sku":"S8682-100MG","price":1915.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809634361689,"sku":"S8682-1G","price":4904.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809634394457,"sku":"S8682-1ML\/DMSO","price":342.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/s8682-amg487-chemical-structure.gif?v=1776204388","url":"https:\/\/absource.de\/products\/amg-487-s8682","provider":"Absource Diagnostics","version":"1.0","type":"link"}