{"product_id":"amsacrine-e4925","title":"Amsacrine","description":"\u003cp\u003e\u003cstrong\u003eAmsacrine\u003c\/strong\u003e is an inhibitor of Topoisomerase used in studies of DNA Damage Response. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control in cancer and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting Topoisomerase, Amsacrine can be used to examine checkpoint activation, DNA repair, and genome-stability control. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cancer and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving Topoisomerase\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Amsacrine is appropriate when a defined chemical perturbant is needed to connect Topoisomerase with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57804977865049,"sku":"E4925-5MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804977897817,"sku":"E4925-25MG","price":488.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804977930585,"sku":"E4925-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57804977963353,"sku":"E4925-1G","price":2918.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E4925-Amsacrine-chemical-structure.png?v=1776170292","url":"https:\/\/absource.de\/products\/amsacrine-e4925","provider":"Absource Diagnostics","version":"1.0","type":"link"}