{"product_id":"anti-muc16-human-structurally-determined-antibody-4h11-clone","title":"Anti-Muc16 (Human) Structurally-determined Antibody (4H11 Clone)","description":"\u003cp\u003e\u003cstrong\u003eAnti-MUC16 (CA125) 4H11\u003c\/strong\u003e is a structurally characterized recombinant monoclonal antibody targeting human MUC16, a large cell-surface mucin also widely known as \u003cstrong\u003eCA125\u003c\/strong\u003e. Derived from the established \u003cstrong\u003e4H11 clone\u003c\/strong\u003e, this antibody provides researchers with a defined reagent for studies involving MUC16 expression, recognition and targeting.\u003c\/p\u003e\n\n\u003cp\u003eA key feature of the 4H11 antibody is the availability of experimentally determined structural information. The structure of its single-chain variable fragment (scFv) has been resolved by \u003cstrong\u003eX-ray crystallography at 2.36 Å resolution\u003c\/strong\u003e and is available in the Protein Data Bank as \u003cstrong\u003ePDB 8VRR\u003c\/strong\u003e. This structural characterization makes the antibody particularly useful for research where detailed knowledge of the antibody variable region can support molecular modelling, antibody engineering, binding studies or the development of MUC16-targeting constructs.\u003c\/p\u003e\n\n\u003ch2\u003eMUC16 \/ CA125 as a Research Target\u003c\/h2\u003e\n\n\u003cp\u003eMUC16 is a high-molecular-weight transmembrane mucin expressed on the surface of several epithelial cell types. It is best known through its extracellular CA125 antigen, which has been extensively studied in cancer biology, particularly in ovarian and other epithelial malignancies. Beyond its use as a biomarker, MUC16 is of interest in research into cell-surface interactions, tumour biology and targeted therapeutic approaches.\u003c\/p\u003e\n\n\u003cp\u003eThe 4H11 clone therefore provides a useful research tool for investigations involving \u003cstrong\u003ehuman MUC16 and CA125\u003c\/strong\u003e, including studies of MUC16-positive cells, antibody-target interactions and the development of experimental MUC16-targeting strategies.\u003c\/p\u003e\n\n\u003ch2\u003eStructurally Defined 4H11 Antibody\u003c\/h2\u003e\n\n\u003cp\u003eAvailability of a high-resolution antibody structure can facilitate more detailed investigation than sequence information alone. Structural data for the 4H11 variable region may support computational analysis of antibody architecture, molecular docking, structure-guided modification and comparative antibody studies.\u003c\/p\u003e\n\n\u003cp\u003eBecause the antibody is produced recombinantly from the 4H11 clone, it also provides a defined and reproducible source of this established anti-MUC16 antibody for ongoing research projects.\u003c\/p\u003e","brand":"BiCell Scientific","offers":[{"title":"50 µg","offer_id":59631861236057,"sku":"BCSD00-50UG","price":445.0,"currency_code":"EUR","in_stock":true},{"title":"250 µg","offer_id":59631861268825,"sku":"BCSD00-250UG","price":950.0,"currency_code":"EUR","in_stock":true},{"title":"1 mg","offer_id":59631861301593,"sku":"BCSD00-1MG","price":2150.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/muc164h11.jpg?v=1790758887","url":"https:\/\/absource.de\/products\/anti-muc16-human-structurally-determined-antibody-4h11-clone","provider":"Absource Diagnostics","version":"1.0","type":"link"}