{"product_id":"anxa2-antibody-sc-f0621","title":"Annexin A2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eAnnexins are a diverse family of over 160 unique proteins found in more than 65 species, ranging from fungi and protists to plants and higher vertebrates. ANXA21 features an amino-terminal domain (ATD) made up of the first 30 amino acids and a carboxyl core domain (CCD) comprising the remaining residues. Depending on the literature source, ANXA2 may also be discussed as Annexin A2 and Annexin-2\/ANXA2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes basement membrane, extracellular matrix, and secreted, which can matter when signal is compared across treatments or changing cell states. Following ANXA2 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eANXA2 is commonly interpreted in the context of cancer, metabolism, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans basement membrane, extracellular matrix, and secreted, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between basement membrane, extracellular matrix, and secreted across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ANXA2. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ANXA2 reflect biology rather than handling. When interpreting ANXA2, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ANXA2 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577492185433,"sku":"F0621-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577492218201,"sku":"F0621-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577492250969,"sku":"F0621-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0621-IF.png?v=1773598706","url":"https:\/\/absource.de\/products\/anxa2-antibody-sc-f0621","provider":"Absource Diagnostics","version":"1.0","type":"link"}