{"product_id":"apremilast-s8034","title":"Apremilast","description":"\u003cp\u003e\u003cstrong\u003eApremilast\u003c\/strong\u003e is an inhibitor of PDE and TNF-alpha used in studies of NF-kB Signaling and Immune Signaling. It is especially relevant in cardiovascular, immunology, and inflammation models, where defined compound exposure can be linked to inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PDE and TNF-alpha, Apremilast can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In cardiovascular, immunology, and inflammation models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PDE and TNF-alpha\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to NF-kB Signaling and Immune Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Apremilast is appropriate when a defined chemical perturbant is needed to connect PDE and TNF-alpha with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cardiovascular, immunology, and inflammation models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809571447129,"sku":"S8034-5MG","price":265.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809571479897,"sku":"S8034-25MG","price":855.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809571512665,"sku":"S8034-1G","price":3921.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809571545433,"sku":"S8034-1ML\/DMSO","price":363.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Apremilast-CC-10004-chemical-structure-s8034.gif?v=1776202228","url":"https:\/\/absource.de\/products\/apremilast-s8034","provider":"Absource Diagnostics","version":"1.0","type":"link"}