{"product_id":"aprepitant-s1189","title":"Aprepitant","description":"\u003cp\u003e\u003cstrong\u003eAprepitant\u003c\/strong\u003e is an antagonist of TNF-alpha and Interleukins used in studies of JAK-STAT Signaling and NF-kB Signaling and related signaling programs. It is especially relevant in immunology, inflammation, and infectious disease models, where defined compound exposure can be linked to cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling.\u003c\/p\u003e\n\n\u003cp\u003eBy blocking TNF-alpha and Interleukins, Aprepitant can be used to examine cytokine-responsive transcriptional signaling and immune regulation and inflammatory transcriptional control and stress-responsive survival signaling. The immunomodulator annotation adds relevance to immune-cell activation, cytokine, and mediator assays, together with downstream-response mapping in the same experimental setting. In immunology, inflammation, and infectious disease models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving TNF-alpha and Interleukins\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and NF-kB Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eReceptor-blockade and ligand-competition studies\u003c\/li\u003e\n\u003cli\u003eImmune-cell activation, cytokine, and mediator assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Aprepitant is appropriate when a defined chemical perturbant is needed to connect TNF-alpha and Interleukins with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in immunology, inflammation, and infectious disease models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805240861017,"sku":"S1189-5MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805240893785,"sku":"S1189-25MG","price":461.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805240926553,"sku":"S1189-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805240959321,"sku":"S1189-1G","price":2938.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Aprepitant-MK-0869-chemical-structure-S1189.gif?v=1776173066","url":"https:\/\/absource.de\/products\/aprepitant-s1189","provider":"Absource Diagnostics","version":"1.0","type":"link"}