{"product_id":"atr-antibody-sc-f0773","title":"ATR Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eThe kinases ATM (ataxia telangiectasia mutated) and ATR (ataxia telangiectasia and Rad3-related) belong to the PI3 kinase-related kinase (PIKK) family. They phosphorylate numerous substrates at serine or threonine residues followed by glutamine, particularly in response to DNA damage or replication obstacles. These kinases serve as crucial detectors of single-stranded DNA, which can arise from stalled replication forks or during processes like base excision repair (BER) and double-strand break repair, acting as intermediates in DNA repair.\u003c\/p\u003e\u003cp\u003eReported cellular context includes chromosome and nucleus, which can matter when signal is compared across treatments or changing cell states. Following ATR across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eATR is commonly interpreted in the context of dna damage \/ repair, cell cycle, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans chromosome and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between chromosome and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003estress-induced changes after checkpoint activation or genotoxic challenge\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for ATR. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in ATR reflect biology rather than handling. When interpreting ATR, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep ATR trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577517449561,"sku":"F0773-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577517482329,"sku":"F0773-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577517515097,"sku":"F0773-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0773-wb.gif?v=1773598919","url":"https:\/\/absource.de\/products\/atr-antibody-sc-f0773","provider":"Absource Diagnostics","version":"1.0","type":"link"}