{"product_id":"axin1-antibody-sc-f0423","title":"Axin1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eAxin1 (Axis inhibition protein 1) and Axin2 are scaffold proteins with multiple domains, functioning as negative regulators of Wnt signaling. Axin1 interacts with APC, GSK-3β, Dvl, and β-catenin, facilitating GSK-3β-mediated phosphorylation and subsequent degradation of β-catenin. Upon Wnt stimulation, Axin1 is recruited to the membrane by phosphorylated LRP5\/6, a process crucial for activating Wnt signaling.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cytoplasm, membrane, and nucleus, which can matter when signal is compared across treatments or changing cell states. Following AXIN1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eAXIN1 is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cytoplasm, and membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cytoplasm, and membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for AXIN1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in AXIN1 reflect biology rather than handling. When interpreting AXIN1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep AXIN1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577451651417,"sku":"F0423-20UL","price":139.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577451684185,"sku":"F0423-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577451716953,"sku":"F0423-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0423-IHC1.jpg?v=1773598449","url":"https:\/\/absource.de\/products\/axin1-antibody-sc-f0423","provider":"Absource Diagnostics","version":"1.0","type":"link"}