{"product_id":"az-960-s2214","title":"AZ 960","description":"\u003cp\u003e\u003cstrong\u003eAZ 960\u003c\/strong\u003e is an inhibitor of JAK and JAK2 used in studies of JAK-STAT Signaling and Apoptosis. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to cytokine-responsive transcriptional signaling and immune regulation and caspase-associated cell-death signaling and survival decisions in apoptosis, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting JAK and JAK2, AZ 960 can be used to examine cytokine-responsive transcriptional signaling and immune regulation and caspase-associated cell-death signaling and survival decisions. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving JAK and JAK2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling and Apoptosis\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, AZ 960 is appropriate when a defined chemical perturbant is needed to connect JAK and JAK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57805467451737,"sku":"S2214-2MG","price":206.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57805467484505,"sku":"S2214-5MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805467517273,"sku":"S2214-10MG","price":560.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805467550041,"sku":"S2214-1G","price":4904.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/AZ-960-chemical-structure-S2214.gif?v=1776174647","url":"https:\/\/absource.de\/products\/az-960-s2214","provider":"Absource Diagnostics","version":"1.0","type":"link"}