{"product_id":"azd1390-s8680","title":"AZD1390","description":"\u003cp\u003e\u003cstrong\u003eAZD1390\u003c\/strong\u003e is an inhibitor of ATM and ATR used in studies of PI3K-Akt-mTOR Signaling and DNA Damage Response. In practice, this places the compound in experiments that measure growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control in cancer, cell signaling, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting ATM and ATR, AZD1390 can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and checkpoint activation, DNA repair, and genome-stability control. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving ATM and ATR\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and DNA Damage Response\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, AZD1390 is appropriate when a defined chemical perturbant is needed to connect ATM and ATR with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57809633935705,"sku":"S8680-2MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57809633968473,"sku":"S8680-5MG","price":213.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809634001241,"sku":"S8680-25MG","price":658.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809634034009,"sku":"S8680-100MG","price":1444.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809634066777,"sku":"S8680-1G","price":5867.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809634099545,"sku":"S8680-1ML\/DMSO","price":321.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/azd1390-chemical-structure-s8680.gif?v=1776204265","url":"https:\/\/absource.de\/products\/azd1390-s8680","provider":"Absource Diagnostics","version":"1.0","type":"link"}