{"product_id":"azd2281-olaparib-s1060","title":"AZD2281 (Olaparib)","description":"\u003cp\u003e\u003cstrong\u003eAZD2281 (Olaparib)\u003c\/strong\u003e is an inhibitor of PARP and PARP1 used in studies of DNA Damage Response and Autophagy. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to checkpoint activation, DNA repair, and genome-stability control and autophagic flux, lysosomal turnover, and stress adaptation in autophagy, cancer, and dna damage \/ repair models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PARP and PARP1, AZD2281 (Olaparib) can be used to examine checkpoint activation, DNA repair, and genome-stability control and autophagic flux, lysosomal turnover, and stress adaptation. The enzyme annotation adds relevance to enzyme-activity assays, substrate-conversion studies, and mechanism profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and dna damage \/ repair models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PARP and PARP1\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Autophagy\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eEnzyme-activity assays, substrate-conversion studies, and mechanism profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, AZD2281 (Olaparib) is appropriate when a defined chemical perturbant is needed to connect PARP and PARP1 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and dna damage \/ repair models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"10 mg","offer_id":57805203800409,"sku":"S1060-10MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805203833177,"sku":"S1060-25MG","price":272.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805203865945,"sku":"S1060-100MG","price":567.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805203898713,"sku":"S1060-1G","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805203931481,"sku":"S1060-1ML\/DMSO","price":272.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Olaparib-AZD2281-chemical-structure-S1060.gif?v=1776172834","url":"https:\/\/absource.de\/products\/azd2281-olaparib-s1060","provider":"Absource Diagnostics","version":"1.0","type":"link"}