{"product_id":"b7h3-antibody-sc-f0878","title":"B7-H3 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eB7H3 is a target of interest in many antibody-based workflows. B7-H3 (CD276) is a member of the B7 family of immune checkpoint proteins, highly expressed in cancer cells and activated immune cells within tumors. It helps cancer cells evade immune detection by cytotoxic T-cells and natural killer cells. Structurally, B7-H3 exists in two human isoforms (2IgB7-H3 and 4IgB7-H3), while mice have only the 2IgB7-H3 form. Depending on the literature source, B7H3 may also be discussed as B7-H3 and CD276.\u003c\/p\u003e\u003cp\u003eReported cellular context includes membrane, which can matter when signal is compared across treatments or changing cell states. Following B7H3 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eB7H3 is commonly interpreted in the context of cancer, immunology, and cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within membrane relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for B7H3. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in B7H3 reflect biology rather than handling. When interpreting B7H3, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep B7H3 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"Selleck \/ 20 µl","offer_id":57577548415321,"sku":"F0878-20UL","price":169.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 100 µl","offer_id":57577548448089,"sku":"F0878-100UL","price":379.0,"currency_code":"EUR","in_stock":true},{"title":"Selleck \/ 2 × 100 µl","offer_id":57577548480857,"sku":"F0878-2X100UL","price":569.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 20 µl","offer_id":58449922916697,"sku":"C05482-20UL","price":136.0,"currency_code":"EUR","in_stock":true},{"title":"Capsid \/ 100 µl","offer_id":58449922949465,"sku":"C05482-100UL","price":323.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F0878-IHC1.jpg?v=1773599046","url":"https:\/\/absource.de\/products\/b7h3-antibody-sc-f0878","provider":"Absource Diagnostics","version":"1.0","type":"link"}