{"product_id":"bace1-antibody-sc-f3242","title":"BACE1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eBACE1 (β-site APP-cleaving enzyme 1), also known as β-secretase, is a membrane-associated aspartyl protease crucial for the initiation of amyloid-β (Aβ) peptide production, a hallmark of Alzheimer's disease (AD) pathology. It cleaves amyloid precursor protein (APP) at the β-site to generate a C-terminal fragment (C99), which is subsequently processed by γ-secretase to produce Aβ peptides, particularly the pathogenic Aβ42 variant. Depending on the literature source, BACE1 may also be discussed as BACE; KIAA1149; BACE1; Beta-secretase 1; Aspartyl protease 2; Beta-site amyloid precursor protein cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2; ASP2; Asp 2; Beta-site APP cleaving enzyme 1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes p56817, which can matter when signal is compared across treatments or changing cell states. Following BACE1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eBACE1 is commonly interpreted in the context of neuroscience research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans p56817, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within p56817 relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for BACE1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in BACE1 reflect biology rather than handling. When interpreting BACE1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep BACE1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578011263321,"sku":"F3242-20UL","price":129.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578011296089,"sku":"F3242-100UL","price":259.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578011328857,"sku":"F3242-2X100UL","price":389.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3242-wb.gif?v=1773601054","url":"https:\/\/absource.de\/products\/bace1-antibody-sc-f3242","provider":"Absource Diagnostics","version":"1.0","type":"link"}