{"product_id":"beta-antibody-sc-f1206","title":"Phospho-PKA α\/β\/γ (catalytic subunit) (T197) Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eBETA is a target of interest in many antibody-based workflows. Phospho-PKA α\/β\/γ (catalytic subunit) (Thr 197) is the catalytic subunit of protein kinase A (PKA) and a key enzyme in cAMP-dependent signaling, existing in α, β, and γ isoforms with tissue-specific expression. Structurally, it has an N-lobe containing the ATP-binding site and a C-lobe essential for substrate interaction. Depending on the literature source, BETA may also be discussed as Phospho-PKA alpha\/beta\/gamma (catalytic subunit) (T197) and Phospho-PKA C (Thr197).\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, cell projection, cilium, and cytoplasm, which can matter when signal is compared across treatments or changing cell states. Following BETA across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eBETA is commonly interpreted in the context of cell signaling research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, cell projection, and cilium, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cell membrane, cell projection, and cilium across matched conditions\u003c\/li\u003e\n\u003cli\u003esignal-dependent shifts after ligand, inhibitor, or growth-factor perturbation\u003c\/li\u003e\n\u003cli\u003edifferences between total target abundance and site-specific regulation when modified forms are compared\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for BETA. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in BETA reflect biology rather than handling. When interpreting BETA, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep BETA trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577659203929,"sku":"F1206-20UL","price":159.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577659236697,"sku":"F1206-100UL","price":389.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577659269465,"sku":"F1206-2X100UL","price":579.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1206-wb.gif?v=1773599434","url":"https:\/\/absource.de\/products\/beta-antibody-sc-f1206","provider":"Absource Diagnostics","version":"1.0","type":"link"}