{"product_id":"bibf-1120-nintedanib-s1010","title":"BIBF 1120 (Nintedanib)","description":"\u003cp\u003e\u003cstrong\u003eBIBF 1120 (Nintedanib)\u003c\/strong\u003e is an inhibitor of PDGFR and VEGFR and related targets used in studies of MAPK \/ ERK Signaling and JAK-STAT Signaling. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation in angiogenesis, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting PDGFR and VEGFR and related targets, BIBF 1120 (Nintedanib) can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In angiogenesis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving PDGFR and VEGFR and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and JAK-STAT Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, BIBF 1120 (Nintedanib) is appropriate when a defined chemical perturbant is needed to connect PDGFR and VEGFR and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in angiogenesis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805167984985,"sku":"S1010-5MG","price":173.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805168017753,"sku":"S1010-50MG","price":658.0,"currency_code":"EUR","in_stock":true},{"title":"200 mg","offer_id":57805168050521,"sku":"S1010-200MG","price":1248.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805168083289,"sku":"S1010-1G","price":2918.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805168116057,"sku":"S1010-1ML\/DMSO","price":235.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/BIBF1120-Vargatef-chemical-structure-S1010.gif?v=1776172726","url":"https:\/\/absource.de\/products\/bibf-1120-nintedanib-s1010","provider":"Absource Diagnostics","version":"1.0","type":"link"}