{"product_id":"bml-277-chk2-inhibitor-ii-s8632","title":"BML-277 (Chk2 Inhibitor II)","description":"\u003cp\u003e\u003cstrong\u003eBML-277 (Chk2 Inhibitor II)\u003c\/strong\u003e is an inhibitor of CHK and CHK2 used in studies of DNA Damage Response and Apoptosis. In practice, this places the compound in experiments that measure checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions in apoptosis, cancer, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting CHK and CHK2, BML-277 (Chk2 Inhibitor II) can be used to examine checkpoint activation, DNA repair, and genome-stability control and caspase-associated cell-death signaling and survival decisions. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving CHK and CHK2\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to DNA Damage Response and Apoptosis\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, BML-277 (Chk2 Inhibitor II) is appropriate when a defined chemical perturbant is needed to connect CHK and CHK2 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809629446489,"sku":"S8632-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809629479257,"sku":"S8632-25MG","price":363.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809629512025,"sku":"S8632-100MG","price":678.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809629544793,"sku":"S8632-1G","price":1936.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809629577561,"sku":"S8632-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/chk2-inhibitor-2-bml-277-chemical-structure-s8632.gif?v=1776203323","url":"https:\/\/absource.de\/products\/bml-277-chk2-inhibitor-ii-s8632","provider":"Absource Diagnostics","version":"1.0","type":"link"}