{"product_id":"brepocitinib-pf-06700841-s8804","title":"Brepocitinib (PF-06700841)","description":"\u003cp\u003e\u003cstrong\u003eBrepocitinib (PF-06700841)\u003c\/strong\u003e is an inhibitor of JAK1 and JAK2 and related targets used in studies of JAK-STAT Signaling. In practice, this places the compound in experiments that measure cytokine-responsive transcriptional signaling and immune regulation in cancer, cell signaling, and immunology models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting JAK1 and JAK2 and related targets, Brepocitinib (PF-06700841) can be used to examine cytokine-responsive transcriptional signaling and immune regulation. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In cancer, cell signaling, and immunology models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving JAK1 and JAK2 and related targets\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to JAK-STAT Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Brepocitinib (PF-06700841) is appropriate when a defined chemical perturbant is needed to connect JAK1 and JAK2 and related targets with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in cancer, cell signaling, and immunology models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809651663193,"sku":"S8804-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809651695961,"sku":"S8804-25MG","price":461.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809651728729,"sku":"S8804-1G","price":4904.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/pf-06700841-chemical-structure-s8804.gif?v=1776204766","url":"https:\/\/absource.de\/products\/brepocitinib-pf-06700841-s8804","provider":"Absource Diagnostics","version":"1.0","type":"link"}