{"product_id":"brigimadlin-e1491","title":"Brigimadlin","description":"\u003cp\u003e\u003cstrong\u003eBrigimadlin\u003c\/strong\u003e is an inhibitor of MDM2 and MDMX used in studies of Apoptosis and Protein Degradation \/ Proteasome. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to caspase-associated cell-death signaling and survival decisions and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation in apoptosis, cancer, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting MDM2 and MDMX, Brigimadlin can be used to examine caspase-associated cell-death signaling and survival decisions and ubiquitin-dependent turnover, proteostasis, and targeted protein degradation. This context is compatible with apoptosis, viability, and caspase-readout assays and degradation, proteasome, and protein-turnover assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving MDM2 and MDMX\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to Apoptosis and Protein Degradation \/ Proteasome\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in apoptosis, cancer, and cell cycle models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Brigimadlin is appropriate when a defined chemical perturbant is needed to connect MDM2 and MDMX with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"1 mg","offer_id":57804401279321,"sku":"E1491-1MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57804401312089,"sku":"E1491-5MG","price":341.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57804401344857,"sku":"E1491-25MG","price":763.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57804401377625,"sku":"E1491-100MG","price":1739.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/E1491-Brigimadlin-chemical-structure.png?v=1776166939","url":"https:\/\/absource.de\/products\/brigimadlin-e1491","provider":"Absource Diagnostics","version":"1.0","type":"link"}