{"product_id":"bubr1-antibody-sc-f2942","title":"BubR1 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eBubR1 (Budding Uninhibited by Benzimidazoles-Related 1) is a multidomain serine\/threonine kinase that plays a pivotal role in the mitotic spindle assembly checkpoint (SAC), a critical surveillance mechanism ensuring accurate chromosome segregation during mitosis. It is expressed throughout the cell cycle and functions primarily by delaying anaphase onset until all chromosomes achieve proper bipolar attachment to the spindle apparatus. Depending on the literature source, BUBR1 may also be discussed as MAD3L and SSK1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes centromere, chromosome, cytoplasm, and cytoskeleton, which can matter when signal is compared across treatments or changing cell states. Following BUBR1 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eBUBR1 is commonly interpreted in the context of neuroscience and cell cycle research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans centromere, chromosome, and cytoplasm, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between centromere, chromosome, and cytoplasm across matched conditions\u003c\/li\u003e\n\u003cli\u003ecompartment-specific patterns relevant to neuronal polarity, transport, or synaptic context\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for BUBR1. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in BUBR1 reflect biology rather than handling. When interpreting BUBR1, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep BUBR1 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577986818393,"sku":"F2942-20UL","price":149.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577986851161,"sku":"F2942-100UL","price":329.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577986883929,"sku":"F2942-2X100UL","price":489.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F2942-IF.png?v=1773600829","url":"https:\/\/absource.de\/products\/bubr1-antibody-sc-f2942","provider":"Absource Diagnostics","version":"1.0","type":"link"}