{"product_id":"canagliflozin-jnj-28431754-s2760","title":"Canagliflozin (JNJ-28431754)","description":"\u003cp\u003e\u003cstrong\u003eCanagliflozin (JNJ-28431754)\u003c\/strong\u003e is an inhibitor of SGLT2 and SGLT used in studies of GPCR Signaling and Metabolic Signaling. It is especially relevant in endocrinology and metabolism models, where defined compound exposure can be linked to receptor-driven second-messenger signaling and desensitization dynamics and metabolic regulation, energy sensing, and enzyme-linked homeostasis.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting SGLT2 and SGLT, Canagliflozin (JNJ-28431754) can be used to examine receptor-driven second-messenger signaling and desensitization dynamics and metabolic regulation, energy sensing, and enzyme-linked homeostasis. The transporter annotation adds relevance to transport, uptake\/efflux, and permeability assays, together with downstream-response mapping in the same experimental setting. In endocrinology and metabolism models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving SGLT2 and SGLT\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to GPCR Signaling and Metabolic Signaling\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eTransport, uptake\/efflux, and permeability assays\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, Canagliflozin (JNJ-28431754) is appropriate when a defined chemical perturbant is needed to connect SGLT2 and SGLT with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in endocrinology and metabolism models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57805713637721,"sku":"S2760-5MG","price":144.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57805713670489,"sku":"S2760-10MG","price":223.0,"currency_code":"EUR","in_stock":true},{"title":"50 mg","offer_id":57805713703257,"sku":"S2760-50MG","price":341.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57805713736025,"sku":"S2760-1G","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57805713768793,"sku":"S2760-1ML\/DMSO","price":193.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/Canagliflozin-chemical-structure-s2760.gif?v=1776175650","url":"https:\/\/absource.de\/products\/canagliflozin-jnj-28431754-s2760","provider":"Absource Diagnostics","version":"1.0","type":"link"}