{"product_id":"cbl0137-hydrochloride-s8483","title":"CBL0137 Hydrochloride","description":"\u003cp\u003e\u003cstrong\u003eCBL0137 Hydrochloride\u003c\/strong\u003e is an activator of p53 and NF-kB used in studies of NF-kB Signaling and Immune Signaling and related signaling programs. In practice, this places the compound in experiments that measure inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses in apoptosis, cancer, and cell cycle models.\u003c\/p\u003e\n\n\u003cp\u003eBy activating p53 and NF-kB, CBL0137 Hydrochloride can be used to examine inflammatory transcriptional control and stress-responsive survival signaling and cytokine-mediated signaling and inflammatory effector responses. This context is compatible with NF-kB reporter, cytokine, and inflammation assays and immune activation, cytokine-response, and mediator-profiling assays, as well as transcriptional, biochemical, or phenotypic comparisons linked to the annotated pathway state. In apoptosis, cancer, and cell cycle models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving p53 and NF-kB\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to NF-kB Signaling and Immune Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eGain-of-function pathway-activation studies\u003c\/li\u003e\n\u003cli\u003ePhenotypic profiling in apoptosis, cancer, and cell cycle models\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, CBL0137 Hydrochloride is appropriate when a defined chemical perturbant is needed to connect p53 and NF-kB with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell cycle models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809613586777,"sku":"S8483-5MG","price":167.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57809613619545,"sku":"S8483-25MG","price":560.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57809613652313,"sku":"S8483-100MG","price":953.0,"currency_code":"EUR","in_stock":true},{"title":"1 g","offer_id":57809613685081,"sku":"S8483-1G","price":1444.0,"currency_code":"EUR","in_stock":true},{"title":"1 ml (10mM\/DMSO)","offer_id":57809613717849,"sku":"S8483-1ML\/DMSO","price":265.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/cbl0137-cbl-0137-chemical-structure-s8483.gif?v=1776202754","url":"https:\/\/absource.de\/products\/cbl0137-hydrochloride-s8483","provider":"Absource Diagnostics","version":"1.0","type":"link"}