{"product_id":"cd49b-antibody-sc-f1694","title":"Integrin α2 Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eIntegrin alpha 2 (Integrin α2, CD49b) is a vital adhesion receptor that forms a heterodimer with integrin β1, creating the α2β1 integrin complex. This receptor is integral to interactions with various extracellular matrix (ECM) components, such as collagen, laminin, and fibronectin. It is crucial for cell adhesion, migration, and force generation within the ECM, and plays a significant role in processes like platelet aggregation and stem cell differentiation. Depending on the literature source, CD49B may also be discussed as Integrin alpha2 and ITGA2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cell membrane, which can matter when signal is compared across treatments or changing cell states. Following CD49B across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state. In practice, this target is often considered at the family or isoform-group level, so experimental interpretation benefits from matched controls and clear comparison logic.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCD49B is commonly interpreted in the context of cancer, immunology, and developmental biology research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cell membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003esignal enrichment within cell membrane relative to the broader cellular background\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003econtext differences tied to immune-cell state, activation, or lineage composition\u003c\/li\u003e\n\u003cli\u003estage-dependent patterns during differentiation, morphogenesis, or lineage commitment\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CD49B. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CD49B reflect biology rather than handling. When interpreting CD49B, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CD49B trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57577821897049,"sku":"F1694-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57577821929817,"sku":"F1694-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57577821962585,"sku":"F1694-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F1694-IHC1.jpg?v=1773600035","url":"https:\/\/absource.de\/products\/cd49b-antibody-sc-f1694","provider":"Absource Diagnostics","version":"1.0","type":"link"}