{"product_id":"cdkn2a-p16ink4a-antibody-sc-f3773","title":"CDKN2A\/p16INK4a Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eCDKN2A\/p16INK4a is a target of interest in many antibody-based workflows. CDKN2A encodes p16INK4a, a key tumor suppressor protein belonging to the INK4 family, characterized by four ankyrin repeats critical for binding cyclin-dependent kinases 4 and 6 (CDK4\/6). The primary function of p16INK4a is to inhibit CDK4\/6 activity, preventing phosphorylation of the retinoblastoma protein (Rb), thereby halting cell cycle progression from the G1 to S phase through blocking the release of E2F transcription factors. Depending on the literature source, CDKN2A\/p16INK4a may also be discussed as CDKN2A\/p16INK4a and CDKN2.\u003c\/p\u003e\u003cp\u003eReported cellular context includes cytoplasm and nucleus, which can matter when signal is compared across treatments or changing cell states. Following CDKN2A\/p16INK4a across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCDKN2A\/p16INK4a is commonly interpreted in the context of cancer, cell cycle, and aging research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans cytoplasm and nucleus, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between cytoplasm and nucleus across matched conditions\u003c\/li\u003e\n\u003cli\u003echanges associated with proliferative state, oncogenic signaling, or treatment response\u003c\/li\u003e\n\u003cli\u003ecell-cycle linked differences in abundance, timing, or compartmental enrichment\u003c\/li\u003e\n\u003cli\u003econtext changes tied to cellular senescence, long-term stress adaptation, or tissue aging\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for CDKN2A\/p16INK4a. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in CDKN2A\/p16INK4a reflect biology rather than handling. When interpreting CDKN2A\/p16INK4a, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep CDKN2A\/p16INK4a trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578045964633,"sku":"F3773-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578045997401,"sku":"F3773-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578046030169,"sku":"F3773-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3773-IF.png?v=1773601469","url":"https:\/\/absource.de\/products\/cdkn2a-p16ink4a-antibody-sc-f3773","provider":"Absource Diagnostics","version":"1.0","type":"link"}