{"product_id":"cgp-57380-s7421","title":"CGP 57380","description":"\u003cp\u003e\u003cstrong\u003eCGP 57380\u003c\/strong\u003e is an inhibitor of MNK used in studies of MAPK \/ ERK Signaling and Wnt Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and beta-catenin-dependent transcription and developmental signaling in apoptosis, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting MNK, CGP 57380 can be used to examine mitogenic kinase cascades, proliferation control, and differentiation-linked signaling and beta-catenin-dependent transcription and developmental signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In apoptosis, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving MNK\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to MAPK \/ ERK Signaling and Wnt Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, CGP 57380 is appropriate when a defined chemical perturbant is needed to connect MNK with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in apoptosis, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"5 mg","offer_id":57809482678617,"sku":"S7421-5MG","price":114.0,"currency_code":"EUR","in_stock":true},{"title":"10 mg","offer_id":57809482711385,"sku":"S7421-10MG","price":183.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/cgp-57380-chemical-structure-s7421.gif?v=1776201357","url":"https:\/\/absource.de\/products\/cgp-57380-s7421","provider":"Absource Diagnostics","version":"1.0","type":"link"}