{"product_id":"chir-99021-laduviglusib-s1263","title":"CHIR-99021 (Laduviglusib)","description":"\u003cp\u003e\u003cstrong\u003eCHIR-99021 (Laduviglusib)\u003c\/strong\u003e is an inhibitor of GSK-3 used in studies of PI3K-Akt-mTOR Signaling and Wnt Signaling and related signaling programs. It is especially relevant when investigators need a named chemical input and interpretable readouts connected to growth-factor signaling, survival control, and nutrient-sensing outputs and beta-catenin-dependent transcription and developmental signaling in autophagy, cancer, and cell signaling models.\u003c\/p\u003e\n\n\u003cp\u003eBy inhibiting GSK-3, CHIR-99021 (Laduviglusib) can be used to examine growth-factor signaling, survival control, and nutrient-sensing outputs and beta-catenin-dependent transcription and developmental signaling. The kinase annotation adds relevance to biochemical kinase assays, phospho-signaling studies, and selectivity profiling, together with downstream-response mapping in the same experimental setting. In autophagy, cancer, and cell signaling models, these readouts can be combined with viability, reporter, localization, biochemical conversion, or morphology endpoints to refine experimental interpretation.\u003c\/p\u003e\n\n\u003ch2\u003eResearch Applications\u003c\/h2\u003e\u003cul\u003e\n\u003cli\u003eTarget-focused assays involving GSK-3\u003c\/li\u003e\n\u003cli\u003ePathway perturbation studies connected to PI3K-Akt-mTOR Signaling and Wnt Signaling and related signaling programs\u003c\/li\u003e\n\u003cli\u003eConcentration-response inhibition and target-dependence studies\u003c\/li\u003e\n\u003cli\u003eBiochemical kinase assays, phospho-signaling studies, and selectivity profiling\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003eOverall, CHIR-99021 (Laduviglusib) is appropriate when a defined chemical perturbant is needed to connect GSK-3 with measurable biochemical, transcriptional, electrophysiological, imaging, or phenotypic readouts in autophagy, cancer, and cell signaling models. This profile is suited to mechanistic follow-up, comparative profiling, and assay optimization under defined exposure conditions.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"2 mg","offer_id":57805258948953,"sku":"S1263-2MG","price":193.0,"currency_code":"EUR","in_stock":true},{"title":"5 mg","offer_id":57805258981721,"sku":"S1263-5MG","price":272.0,"currency_code":"EUR","in_stock":true},{"title":"25 mg","offer_id":57805259014489,"sku":"S1263-25MG","price":665.0,"currency_code":"EUR","in_stock":true},{"title":"100 mg","offer_id":57805259047257,"sku":"S1263-100MG","price":1248.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/CHIR99021-chemical-structure-s1263.gif?v=1776173240","url":"https:\/\/absource.de\/products\/chir-99021-laduviglusib-s1263","provider":"Absource Diagnostics","version":"1.0","type":"link"}