{"product_id":"cox4-antibody-sc-f3930","title":"OxPhos Complex IV subunit IV Antibody","description":"\u003ch2\u003eAbout the Target\u003c\/h2\u003e\u003cp\u003eOxPhos Complex IV subunit IV (COX4) is a critical nuclear-encoded subunit of Complex IV, also known as cytochrome c oxidase (COX)-the terminal enzyme in the mitochondrial electron transport chain. Complex IV catalyzes the transfer of electrons from cytochrome c to molecular oxygen, reducing it to water and simultaneously pumping protons across the inner mitochondrial membrane to establish the proton-motive force required for ATP synthesis. Depending on the literature source, COX4 may also be discussed as OxPhos Complex IV subunit IV and Cytochrome c oxidase subunit 4 isoform 1.\u003c\/p\u003e\u003cp\u003eReported cellular context includes membrane, mitochondrion, and mitochondrion inner membrane, which can matter when signal is compared across treatments or changing cell states. Following COX4 across matched perturbations can help separate abundance effects from shifts in localization, complex assembly, or pathway state.\u003c\/p\u003e\u003ch2\u003eResearch Context\u003c\/h2\u003e\u003cp\u003eCOX4 is commonly interpreted in the context of metabolism research, and readouts are often stronger when a study separates expression changes from compartment-level redistribution. When reported signal spans membrane, mitochondrion, and mitochondrion inner membrane, a defined reference condition can make comparisons more interpretable across perturbations, passages, or replicate sets.\u003c\/p\u003e\u003cp\u003eConsider these angles when interpreting target-level changes:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eapparent redistribution between membrane, mitochondrion, and mitochondrion inner membrane across matched conditions\u003c\/li\u003e\n\u003cli\u003eresponses linked to nutrient status, mitochondrial state, or metabolic rewiring\u003c\/li\u003e\n\u003cli\u003eco-patterning with orthogonal markers and control conditions that clarify pathway state\u003c\/li\u003e\n\u003cli\u003etime-matched comparisons so changes reflect biology rather than handling or sampling drift\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch2\u003eVariant Considerations\u003c\/h2\u003e\u003cp\u003eIf your project spans exploratory questions, the regular version offers a balanced option for establishing baseline signal behavior for COX4. This can help when protocols evolve over time and the goal is to compare experiments using a stable reference workflow.\u003c\/p\u003e\u003cp\u003eStandardize sampling time, control choice, and downstream analysis thresholds so apparent differences in COX4 reflect biology rather than handling. When interpreting COX4, it is often useful to decide early whether the main question is overall abundance, compartmental enrichment, or context-dependent redistribution.\u003c\/p\u003e\u003cp\u003eFor multi-run studies, a shared reference condition can keep COX4 trends easier to compare across datasets. That kind of consistency is especially helpful when follow-up work expands to new perturbations, model systems, or longitudinal collections.\u003c\/p\u003e","brand":"Selleck Chemicals","offers":[{"title":"20 µl","offer_id":57578052419929,"sku":"F3930-20UL","price":199.0,"currency_code":"EUR","in_stock":true},{"title":"100 µl","offer_id":57578052452697,"sku":"F3930-100UL","price":489.0,"currency_code":"EUR","in_stock":true},{"title":"2 × 100 µl","offer_id":57578052485465,"sku":"F3930-2X100UL","price":729.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0923\/1011\/0553\/files\/F3930-wb.gif?v=1773601563","url":"https:\/\/absource.de\/products\/cox4-antibody-sc-f3930","provider":"Absource Diagnostics","version":"1.0","type":"link"}